Context: Within digital ecosystems avoiding the propagation of security and trust violations among interconnected parties is a mandatory requirement, especially when a new device, a software component, or a system component is integrated within the ecosystem. Objective: The aim is to define an auditing framework able to assess and evaluate the specific functional and non-functional properties of the ecosystems and their components. Method: In this paper, we present the concept of predictive simulation and runtime monitoring for detecting malicious behavior of ecosystem components. Results and Conclusion: We defined a reference architecture allowing the automation of the auditing process for the runtime behavior verification of ecosystems and their components. Validation of the proposal with real use-cases is part of the future BIECO’s activities.